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Placental alpha microglobulin-1 (PAMG-1) is a human protein that was first isolated in 1975 from amniotic fluid.PAMG-1 is an important biomarker for the detection of premature rupture of fetal membrane (PROM) The high concentration of PAMG-1 in amniotic fluid means it can be used to detect if this fluid is present in the cervico-vaginal discharge of pregnant women; the presence of PAMG-1 in ...
alpha-2-Macroglobulin. α2-Macroglobulin ( α2M) or alpha-2-macroglobulin is a large (720 KDa) plasma protein found in the blood. It is mainly produced by the liver, and also locally synthesized by macrophages, fibroblasts, and adrenocortical cells. In humans it is encoded by the A2M gene.
Alpha-1 antitrypsin deficiency ( A1AD or AATD) is a genetic disorder that may result in lung disease or liver disease. [ 1] Onset of lung problems is typically between 20 and 50 years of age. [ 1] This may result in shortness of breath, wheezing, or an increased risk of lung infections. [ 1][ 2] Complications may include chronic obstructive ...
Pre-eclampsia is a multi-system disorder specific to pregnancy, characterized by the onset of high blood pressure and often a significant amount of protein in the urine. [1] [8] [9] When it arises, the condition begins after 20 weeks of pregnancy.
Activated protein C resistance ( APCR) is a hypercoagulability (an increased tendency of the blood to clot) characterized by a lack of a response to activated protein C (APC), which normally helps prevent blood from clotting excessively. This results in an increased risk of venous thrombosis (blood clots in veins), which resulting in medical ...
Frequency. ~8% of term pregnancies, [ 2] ~30% of preterm pregnancies [ 4] Prelabor rupture of membranes ( PROM ), previously known as premature rupture of membranes, is breakage of the amniotic sac before the onset of labour. [ 2] Women usually experience a painless gush or a steady leakage of fluid from the vagina. [ 1]
Elevated alpha-fetoprotein refers to a state where alpha-fetoprotein levels are outside of the reference range. There are two categories of AFP tests: tests performed on serum (blood plasma), and tests performed on amniotic fluid. Tests performed on serum are further categorized by the reason for performing the test: maternal serum, adult tumor ...
A small spike would be present in the gamma (γ) band in MGUS. Monoclonal gammopathy of undetermined significance ( MGUS) is a plasma cell dyscrasia in which plasma cells or other types of antibody-producing cells secrete a myeloma protein, i.e. an abnormal antibody, into the blood; this abnormal protein is usually found during standard ...