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Glucan 1,3-β-glucosidase ( EC 3.2.1.58, exo-1,3-β-glucosidase, β-1,3-glucan exo-hydrolase, exo (1→3)-glucanohydrolase, 1,3-β-glucan glucohydrolase) is an enzyme with systematic name 3-β-D-glucan glucohydrolase. [1] [2] It catalyses the successive hydrolysis of β- D - glucose units from the non-reducing ends of (1→3)-β- D -glucans ...
Cellulose is an example of a (1→4)-β- D -glucan composed of glucose units. Beta-glucans, β-glucans comprise a group of β- D -glucose polysaccharides ( glucans) naturally occurring in the cell walls of cereals, bacteria, and fungi, with significantly differing physicochemical properties dependent on source. Typically, β-glucans form a ...
The family consists of various 1,3-beta-glucan synthase components including Gls1, Gls2, and Gls3 from yeast. 1,3-Beta-glucan synthase (EC 2.4.1.34.) also known as callose synthase catalyses the formation of a beta-1,3-glucan polymer that is a major component of the fungal cell wall. [4] The reaction catalysed is:
A glucan is a polysaccharide derived from D- glucose, [1] linked by glycosidic bonds. Glucans are noted in two forms: alpha glucans and beta glucans. Many beta-glucans are medically important. They represent a drug target for antifungal medications of the echinocandin class.
Micafungin is indicated for the treatment of candidemia, acute disseminated candidiasis, Candida peritonitis, abscesses and esophageal candidiasis.. Micafungin works by way of concentration-dependent inhibition of 1,3-beta-D-glucan synthase resulting in reduced formation of 1,3-beta-D-glucan, which is an essential polysaccharide comprising one-third of the majority of Candida spp. cell walls.
Schizophyllan is a β-1,3 beta-glucan with β-1,6 branching. Schizophyllan is also known as sizofiran . Schizophyllan has a molecular weight of 450,000 Da, and a specific rotation in water of +18-24°. A chemically analogous polysaccharide, scleroglucan, is formed by the fungus Athelia rolfsii. Both polysaccharides share the chemical structure ...
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