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Facioscapulohumeral muscular dystrophy ( FSHD) is a type of muscular dystrophy, a group of heritable diseases that cause degeneration of muscle and progressive weakness. Per the name, FSHD tends to sequentially weaken the muscles of the face, those that position the scapula, and those overlying the humerus bone of the upper arm.
Losmapimod ( GW856553X) is an investigational drug being developed by Fulcrum Therapeutics for the treatment of facioscapulohumeral muscular dystrophy (FSHD); a phase III clinical trial is pending approval. Losmapimod selectively inhibits enzymes p38α/β mitogen-activated protein kinases (MAPKs), which are modulators of DUX4 expression and ...
Coats' disease is a rare extramuscular manifestation of facioscapulohumeral muscular dystrophy (FSHD). ... In the early stages, there are a few treatment options.
Winged scapula. The left side of the thorax. (Winging not illustrated but serratus anterior is labeled at left, and trapezius is labeled at upper right.) A winged scapula ( scapula alata) is a skeletal medical condition in which the shoulder blade protrudes from a person's back in an abnormal position. In rare conditions it has the potential to ...
A pertinent example is facioscapulohumeral muscular dystrophy (FSHD), which commonly affects the trapezius, causing a need for scapular stabilization, but also commonly affects other periscapular muscles, which contraindicates the transfer. Collagen disorders contraindicate tendon transfers in general, including the Eden–Lange procedure.
Muscular dystrophies ( MD) are a genetically and clinically heterogeneous group of rare neuromuscular diseases that cause progressive weakness and breakdown of skeletal muscles over time. [1] The disorders differ as to which muscles are primarily affected, the degree of weakness, how fast they worsen, and when symptoms begin. [1]
Tim Newcomb. July 31, 2024 at 8:00 AM. Sarcophagus Sealed for 2,000 Years Finally Openedizanbar - Getty Images. Experts working in the Tomb of Cerberus in Giugliano, an area in Naples, unsealed a ...
Inappropriate expression of DUX4 in muscle cells is the cause of facioscapulohumeral muscular dystrophy (FSHD). [7] [8] Overexpression of DUX4 due to translocations can cause B-cell leukemia. [6] A translocation that merges DUX4 with CIC can cause an aggressive type of sarcoma. [9]