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Losmapimod ( GW856553X) is an investigational drug being developed by Fulcrum Therapeutics for the treatment of facioscapulohumeral muscular dystrophy (FSHD); a phase III clinical trial is pending approval. Losmapimod selectively inhibits enzymes p38α/β mitogen-activated protein kinases (MAPKs), which are modulators of DUX4 expression and ...
Up to 1/8,333 [2] Facioscapulohumeral muscular dystrophy ( FSHD) is a type of muscular dystrophy, a group of heritable diseases that cause degeneration of muscle and progressive weakness. Per the name, FSHD tends to sequentially weaken the muscles of the face, those that position the scapula, and those overlying the humerus bone of the upper arm.
Inappropriate expression of DUX4 in muscle cells is the cause of facioscapulohumeral muscular dystrophy (FSHD). [7] [8] Overexpression of DUX4 due to translocations can cause B-cell leukemia. [6] A translocation that merges DUX4 with CIC can cause an aggressive type of sarcoma. [9]
Stamulumab ( MYO-029 [1]) is an experimental myostatin inhibiting drug developed by Wyeth Pharmaceuticals for the treatment of muscular dystrophy (MD). Stamulumab was formulated and tested by Wyeth in Collegeville, Pennsylvania. [2] Myostatin is a protein that inhibits the growth of muscle tissue, stamulumab is a recombinant human antibody ...
Tim Newcomb. July 31, 2024 at 8:00 AM. Sarcophagus Sealed for 2,000 Years Finally Openedizanbar - Getty Images. Experts working in the Tomb of Cerberus in Giugliano, an area in Naples, unsealed a ...
Meena Upadhyaya OBE, FRCPath, FLSW is an Indian-born Welsh medical geneticist and a Professor emerita at Cardiff University. Her research has focused on the genes that cause various genetic disorders, in particular neurofibromatosis type I and facioscapulohumeral muscular dystrophy .
Muscular dystrophies ( MD) are a genetically and clinically heterogeneous group of rare neuromuscular diseases that cause progressive weakness and breakdown of skeletal muscles over time. [1] The disorders differ as to which muscles are primarily affected, the degree of weakness, how fast they worsen, and when symptoms begin. [1]
Rodrigo Vaz. The death of Richard Simmons is under investigation pending a cause of death from the medical examiner, the Los Angeles Police Department said Monday, two days after the fitness icon ...