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Uncombable hair syndrome ( UHS) is a rare structural anomaly of the hair with a variable degree of effect. It is characterized by hair that is silvery, dry, frizzy, wiry, and impossible to comb. [ 4] It was first reported in the early 20th century. [ 5] It typically becomes apparent between the ages of 3 months and 12 years. [ 6]
Constitutional Symptoms. Unexplained weight loss: Weight loss that is unintended and not explained by diet, exercise or other illness may be a warning sign of many types of cancer. Unexplained pain: Pain that persists, has no clear cause, and does not respond to treatment may be a warning sign of many types of cancers.
Has no known biological role. Medically, it was used for many years to induce hair loss, but this has ended due to its numerous other toxic effects on human health. [10] Its role, if any, in living things other than humans has been very little explored. It is very toxic and there is evidence that the vapor is both teratogenic and carcinogenic. [65]
Dermatology. Non scarring hair loss, also known as noncicatricial alopecia is the loss of hair without any scarring being present. [ 1] There is typically little inflammation and irritation, but hair loss is significant. This is in contrast to scarring hair loss during which hair follicles are replaced with scar tissue as a result of inflammation.
Pattern hair loss (also known as androgenetic alopecia ( AGA) [ 1]) is a hair loss condition that primarily affects the top and front of the scalp. [ 2][ 3] In male-pattern hair loss ( MPHL ), the hair loss typically presents itself as either a receding front hairline, loss of hair on the crown and vertex of the scalp, or a combination of both.
Minoxidil, applied topically, is widely used for the treatment of hair loss. It may be effective in helping promote hair growth in both men and women with androgenic alopecia. [20] [21] About 40% of men experience hair regrowth after 3–6 months. [22] It is the only topical product that is FDA approved in America for androgenic hair loss. [20]
Flutamide has been researched and used extensively in the treatment of androgen-dependent skin and hair conditions in women including acne, seborrhea, hirsutism, and scalp hair loss, as well as in hyperandrogenism (e.g., in polycystic ovary syndrome or congenital adrenal hyperplasia), and is effective in improving the symptoms of these conditions.
Many breast cancer therapies have side effects that can be alleviated with appropriate supportive care. Chemotherapy causes hair loss, nausea, and vomiting in nearly everyone who receives it. Antiemetic drugs can alleviate nausea and vomiting; cooling the scalp with a cold cap during chemotherapy treatments may reduce hair loss. [61]
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