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Phosphoinositide 3-kinases (PI3Ks), also called phosphatidylinositol 3-kinases, are a family of enzymes involved in cellular functions such as cell growth, proliferation, differentiation, motility, survival and intracellular trafficking, which in turn are involved in cancer. PI3Ks are a family of related intracellular signal transducer enzymes ...
The PI3K/AKT/mTOR pathway is an intracellular signaling pathway important in regulating the cell cycle. Therefore, it is directly related to cellular quiescence, proliferation, cancer, and longevity. PI3K activation phosphorylates and activates AKT, localizing it in the plasma membrane. [1] AKT can have a number of downstream effects such as ...
Single-access key. In phylogenetics, a single-access key (also called dichotomous key, sequential key, analytical key, [1] or pathway key) is an identification key where the sequence and structure of identification steps is fixed by the author of the key. At each point in the decision process, multiple alternatives are offered, each leading to ...
The alternative pathway is a type of cascade reaction of the complement system and is a component of the innate immune system, a natural defense against infections. The alternative pathway is one of three complement pathways that opsonize and kill pathogens. The pathway is triggered when the C3b protein directly binds a microbe.
University of Missouri–Kansas City (UMKC), founded in 1933, is the largest school in the Kansas City metropolitan area with 15,327 students (Fall 2023). [6] It offers over 150 degree programs through 12 schools and colleges, but is best known for its programs in health sciences, entrepreneurship programs, and its Conservatory of Music and Dance.
Amino acid biosynthesis is the set of biochemical processes (metabolic pathways) by which the amino acids are produced. The substrates for these processes are various compounds in the organism 's diet or growth media. Not all organisms are able to synthesize all amino acids. For example, humans can synthesize 11 of the 20 standard amino acids.
Accessory pathway. In cardiology, an accessory pathway is an additional electrical connection between two parts of the heart. [1] These pathways can lead to abnormal heart rhythms (arrhythmias) associated with symptoms of palpitations. Some pathways may activate a region of ventricular muscle earlier than would normally occur, referred to as ...
Carbohydrate metabolism is the whole of the biochemical processes responsible for the metabolic formation, breakdown, and interconversion of carbohydrates in living organisms. Carbohydrates are central to many essential metabolic pathways. [1] Plants synthesize carbohydrates from carbon dioxide and water through photosynthesis, allowing them to ...