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The Nutcracker ( Russian: Щелкунчик[ a ], romanized :Shchelkunchik, pronounced [ɕːɪɫˈkunʲt͡ɕɪk] ⓘ ), Op. 71, is an 1892 two-act classical ballet (conceived as a ballet-féerie; Russian: балет-феерия, romanized:balet-feyeriya) by Pyotr Ilyich Tchaikovsky, set on Christmas Eve at the foot of a Christmas tree in a ...
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Bupropion was originally called by the generic name amfebutamone, before being renamed in 2000. [ 16] In 2021, it was the eighteenth most commonly prescribed medication in the United States, with more than 29 million prescriptions. [ 38][ 39] It is on the World Health Organization's List of Essential Medicines.
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It has a bioavailability of 20-40%, reaches peak plasma concentration in about 45 minutes, and in healthy subjects has an average half-life of 5 hours (observed range 2 - 10 hours). [7] Scopolamine is primarily metabolized by the CYP3A4 enzyme, and Grapefruit juice decreases metabolism of scopolamine, consequently increasing plasma concentration.
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