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Milbemycins are products of fermentation by Streptomyces species. They have a similar mechanism of action, but a longer half-life than the avermectins. Milbemycin oxime is produced by Streptomyces hygroscopicus aureolacrimosus. It opens glutamate sensitive chloride channels in neurons and myocytes of invertebrates, leading to hyperpolarisation ...
Lufenuron is the active ingredient in the veterinary flea control medication Program, and one of the two active ingredients in the flea, heartworm, and anthelmintic medicine milbemycin oxime/lufenuron (Sentinel). Lufenuron is stored in the animal's body fat and transferred to adult fleas through the host's blood when they feed.
The combination milbemycin oxime/lufenuron (trade names Sentinel Flavor Tabs, by Novartis Animal Health, and Program plus) is a parasite control drug in which the active ingredient, milbemycin oxime, eliminates worms, while a second active ingredient, lufenuron, arrests the development of eggs and larvae, preventing them from maturing and continuing the infestation of an animal.
Feline lower urinary tract disease. Feline lower urinary tract disease (FLUTD) is a generic category term to describe any disorder affecting the bladder or urethra of cats. [1] It encompasses around 10 different diseases of the lower urinary tract, all of which can present with very similar symptoms: [2] Some of these symptoms may be the result ...
Fluralaner, [12] sold under the brand name Bravecto among others, is a systemic insecticide and acaricide that is administered orally [13] or topically. [14] The US Food and Drug Administration (FDA) approved it for flea treatment in dogs in May 2014, [15] and approved the combination fluralaner/moxidectin (Bravecto Plus) as a topical treatment for cats in November 2019.
Lotilaner, sold under the brand name Credelio among others, is a veterinary medication used to control fleas and ticks in dogs and cats. [2] [3] [4] [12] It is indicated for the treatment and prevention of flea infestations (Ctenocephalides felis) and for the treatment and control of tick infestations including lone star tick (Amblyomma americanum), American dog tick (Dermacentor variabilis ...
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