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Curtius rearrangement. The Curtius rearrangement (or Curtius reaction or Curtius degradation ), first defined by Theodor Curtius in 1885, is the thermal decomposition of an acyl azide to an isocyanate with loss of nitrogen gas. [1] [2] The isocyanate then undergoes attack by a variety of nucleophiles such as water, alcohols and amines, to yield ...
The Pictet–Spengler reaction is a chemical reaction in which a β-arylethylamine undergoes condensation with an aldehyde or ketone followed by ring closure. The reaction was first discovered in 1911 by Amé Pictet and Theodor Spengler (22 February 1886 – 18 August 1965). [1] Traditionally, an acidic catalyst in protic solvent was employed ...
mechanism. In organic chemistry, the Ei mechanism ( Elimination Internal/Intramolecular ), also known as a thermal syn elimination or a pericyclic syn elimination, is a special type of elimination reaction in which two vicinal (adjacent) substituents on an alkane framework leave simultaneously via a cyclic transition state to form an alkene in ...
Phencyclidine or phenylcyclohexyl piperidine ( PCP ), also known in its use as a street drug as angel dust among other names, is a dissociative anesthetic mainly used recreationally for its significant mind-altering effects. [1] [5] PCP may cause hallucinations, distorted perceptions of sounds, and violent behavior.
The reaction is a variant of the Gomberg-Bachmann reaction. The following reaction scheme shows the Pschorr cyclization for the example of phenanthrene: Pschorr-Cyclisierung Reaction mechanism. In the course of the Pschorr cyclization, a diazotization of the starting compound occurs, so that an aryldiazonium salt is formed as intermediate.
Bamberger rearrangement. The Bamberger rearrangement is the chemical reaction of phenylhydroxylamines with strong aqueous acid, which will rearrange to give 4-aminophenols. [1] It is named for the German chemist Eugen Bamberger (1857–1932). [2] [3]
Williamson ether synthesis. The Williamson ether synthesis is an organic reaction, forming an ether from an organohalide and a deprotonated alcohol ( alkoxide ). This reaction was developed by Alexander Williamson in 1850. [2] Typically it involves the reaction of an alkoxide ion with a primary alkyl halide via an S N 2 reaction.
The mechanism of the Pummerer rearrangement begins with the acylation of the sulfoxide (resonance structures 1 and 2) by acetic anhydride to give 3, with acetate as byproduct. The acetate then acts as a catalyst to induce an elimination reaction to produce the cationic- thial structure 4 , with acetic acid as byproduct.