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Hit to lead (H2L) also known as lead generation is a stage in early drug discovery where small molecule hits from a high throughput screen (HTS) are evaluated and undergo limited optimization to identify promising lead compounds. [1][2] These lead compounds undergo more extensive optimization in a subsequent step of drug discovery called lead ...
exemplifies the possible results of the test: If p ≤ 0, then the term test identifies the series as divergent. If 0 < p ≤ 1, then the term test is inconclusive, but the series is divergent by the integral test for convergence. If 1 < p, then the term test is inconclusive, but the series is convergent, again by the integral test for convergence.
exists there are three possibilities: if L > 1 the series converges (this includes the case L = ∞) if L < 1 the series diverges. and if L = 1 the test is inconclusive. An alternative formulation of this test is as follows. Let { an } be a series of real numbers. Then if b > 1 and K (a natural number) exist such that.
v. t. e. Pharmacogenomics, often abbreviated "PGx," is the study of the role of the genome in drug response. Its name (pharmaco- + genomics) reflects its combining of pharmacology and genomics. Pharmacogenomics analyzes how the genetic makeup of a patient affects their response to drugs. [1]
e. In mathematics, Dirichlet's test is a method of testing for the convergence of a series. It is named after its author Peter Gustav Lejeune Dirichlet, and was published posthumously in the Journal de Mathématiques Pures et Appliquées in 1862. [1]
Miscellanea. v. t. e. In mathematical analysis, the alternating series test is the method used to show that an alternating series is convergent when its terms (1) decrease in absolute value, and (2) approach zero in the limit. The test was used by Gottfried Leibniz and is sometimes known as Leibniz's test, Leibniz's rule, or the Leibniz criterion.
Weierstrass M-test. In mathematics, the Weierstrass M-test is a test for determining whether an infinite series of functions converges uniformly and absolutely. It applies to series whose terms are bounded functions with real or complex values, and is analogous to the comparison test for determining the convergence of series of real or complex ...
HP-15C. The HP-15C is a high-end scientific pocket calculator with a root-solver and numerical integration. A member of Hewlett-Packard Voyager series of programmable calculators, it was produced between 1982 and 1989. The calculator is able to handle complex numbers and matrix operations.
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