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Zinc transporter protein. Zinc transporter proteins (Zrt), or simply zinc transporters, are membrane transport proteins of the solute carrier family which control the membrane transport of zinc and regulate its intracellular and cytoplasmic concentrations. [1] They include two major groups: (1) the zinc transporter (ZnT) or solute carrier 30 ...
Zinc transporter ZIP9, also known as Zrt- and Irt-like protein 9 (ZIP9) and solute carrier family 39 member 9, is a protein that in humans is encoded by the SLC39A9 gene. This protein is the 9th member out of 14 ZIP family proteins, which is a membrane androgen receptor (mAR) coupled to G proteins , and also classified as a zinc transporter ...
Basic properties. Zinc transporter ZIP12 is a protein that is encoded by the solute carrier 39 member 12 (SLC39A12) gene. [5] [6] ZIP12 is part of a family of Zrt-like, IRT-like proteins (ZIPs) that transport metals. ZIP12 is most closely related to a similar transporter, ZIP4, which is mutated in the genetic disorder acrodermatitis enteropathica.
Zinc cannot passively diffuse across cell membranes and requires specific transporters, such as SLC39A7, to enter the cytosol from both the extracellular environment and from intracellular storage compartments. [7] The presence of zinc regulates the expression of ZIP transporters. [8] ZIP7 is a membrane transport protein of the endoplasmic ...
Zinc transporter 8. Zinc transporter 8 ( ZNT8) is a protein that in humans is encoded by the SLC30A8 gene. [ 5] ZNT8 is a zinc transporter related to insulin secretion in humans. In particular, ZNT8 is critical for the accumulation of zinc into beta cell secretory granules and the maintenance of stored insulin as tightly packaged hexamers.
Zinc transporter ZIP6. Zinc transporter ZIP6 is a protein that in humans is encoded by the SLC39A6 gene. [5] [6] [7] Zinc is an essential cofactor for hundreds of enzymes. It is involved in protein, nucleic acid, carbohydrate, and lipid metabolism, as well as in the control of gene transcription, growth, development, and differentiation.
Solute carrier family. The solute carrier ( SLC) group of membrane transport proteins include over 400 members organized into 66 families. [ 1][ 2] Most members of the SLC group are located in the cell membrane. The SLC gene nomenclature system was originally proposed by the HUGO Gene Nomenclature Committee ( HGNC) and is the basis for the ...
Zinc transporter ZIP10, also known as solute carrier family 39 member 10, is a protein that in humans is encoded by the SLC39A10 gene. ZIP10 belongs to a subfamily of proteins that show structural characteristics of zinc transporters , and have 14 members in the human genome: ZIP1 , ZIP2, ZIP3, ZIP4, ZIP5, ZIP6, ZIP7 , ZIP8, ZIP9 , ZIP10 ...