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Lipinski's rule of five, also known as Pfizer's rule of five or simply the rule of five (RO5), is a rule of thumb to evaluate druglikeness or determine if a chemical compound with a certain pharmacological or biological activity has chemical properties and physical properties that would likely make it an orally active drug in humans.
pharmacology pharyng-of or pertaining to the pharynx, the upper throat cavity Greek φᾰ́ρῠγξ, φαρυγγ-(phárunx, pharung-), throat, windpipe; chasm pharyngitis, pharyngoscopy-phil(ia) attraction for Greek φῐλῐ́ᾱ (philíā), friendship, love, affection hemophilia: phleb-of or pertaining to the (blood) veins, a vein
In pharmacology, the term mechanism of action ( MOA) refers to the specific biochemical interaction through which a drug substance produces its pharmacological effect. [ 2] A mechanism of action usually includes mention of the specific molecular targets to which the drug binds, such as an enzyme or receptor. [ 3]
Radiopharmacology is radiochemistry applied to medicine and thus the pharmacology of radiopharmaceuticals ( medicinal radiocompounds, that is, pharmaceutical drugs that are radioactive ). Radiopharmaceuticals are used in the field of nuclear medicine as radioactive tracers in medical imaging and in therapy for many diseases (for example ...
The absolute bioavailability is the dose-corrected area under curve ( AUC) non-intravenous divided by AUC intravenous. The formula for calculating the absolute bioavailability, F, of a drug administered orally (po) is given below (where D is dose administered). Therefore, a drug given by the intravenous route will have an absolute ...
These are the items Americans lose most. Perhaps unsurprisingly, the most commonly lost items were also among the most ubiquitous and important: phones and keys. Most people don't leave home ...
Neuropharmacology is the study of how drugs affect function in the nervous system, and the neural mechanisms through which they influence behavior. [ 1] There are two main branches of neuropharmacology: behavioral and molecular. Behavioral neuropharmacology focuses on the study of how drugs affect human behavior ( neuropsychopharmacology ...
Absorption (pharmacology) Absorption is the journey of a drug travelling from the site of administration to the site of action. [ 1 ][ 2 ] The drug travels by some route of administration ( oral, topical-dermal, etc.) in a chosen dosage form (e.g., tablets, capsules, or in solution ). [ 3 ] Absorption by some other routes, such as intravenous ...