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6% (< 60 years old), 20% (> 60 years old) [ 4 ] Vitamin B12 deficiency, also known as cobalamin deficiency, is the medical condition in which the blood and tissue have a lower than normal level of vitamin B 12. [ 5 ] Symptoms can vary from none to severe. [ 1 ] Mild deficiency may have few or absent symptoms. [ 1 ]
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Diagnosis is supported based on vitamin B 12 blood levels below 150–180 pmol/L (200–250 pg/mL) in adults. [50] However, serum values can be maintained while tissue B 12 stores are becoming depleted. Therefore, serum B 12 values above the cut-off point of deficiency do not necessarily confirm adequate B 12 status. [2]
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The Schilling test distinguished PA from other forms of B 12 deficiency, [50] specifically, from Imerslund–Gräsbeck syndrome, a B 12-deficiency caused by mutations in CUBN that codes for cubilin the cobalamin receptor. [1] Vitamin B12 deficiency is also prevalent in patients having Crohn's disease (CD) so it should be differentiated. [62]
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