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A prodrug is an inactive medication, but once it enters the body, the body turns it into an active form so that the medication can have its intended effect. This article will provide a definition of a prodrug, examples, and explain its use in medicine. Learn more about prodrugs with GoodRx.
A prodrug is a pharmacologically inactive medication or compound that, after intake, is metabolized (i.e., converted within the body) into a pharmacologically active drug. [1][2] Instead of administering a drug directly, a corresponding prodrug can be used to improve how the drug is absorbed, distributed, metabolized, and excreted (ADME). [3][4]
Prodrugs are bioreversible, inactive drug derivatives, which have the ability to convert into a parent drug in the body. In the past, prodrugs were used as a last option; however, nowadays, prodrugs are considered already in the early stages of drug development.
A prodrug is a pharmacologically inactive derivative of a parent molecule that requires spontaneous or enzymatic transformation within the body to release the active drug moiety. For targeting drugs to the colon, drug is to be protected from the hostile environments of the stomach and small intestine (SI).
The prodrug, romidepsin is considered as a single-agent therapy that provides durable responses in patients with refractory or relapsed/PTCL. Studies have shown a synergistic effect when romidepsin and pralatrexate were used in a combination with tolerable hematologic toxicity.
A prodrug is by definition a pharmacological inactive derivative of a drug molecule that is capable of releasing the parent molecule quantitatively, due to enzymatic or spontaneous reaction in the body.
This tutorial explains the pharmacokinetics of a prodrug and its active metabolite (or parent drug) using a two-step, consecutive, first-order irreversible reaction as a basic model for prodrug metabolism.