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The adverse effects found in the Phase II trial mainly affected the central nervous system, and appeared to be dose-related. [8] The most common adverse effects were drowsiness, dizziness, tinnitus and vertigo, confusion, and slurred speech. [9] Less common side effects included tremor, memory loss, gait disturbances, and double vision. [10]
Tinnitus. Tinnitus is a variety of sound that is heard when no corresponding external sound is present. [1] Nearly everyone experiences faint "normal tinnitus" in a completely quiet room; but it is of concern only if it is bothersome, interferes with normal hearing, or is associated with other problems. [6]
High blood pressure can cause tinnitus because it increases blood flow force through your veins and arteries, including those around your head, sinuses, and ears. As the blood is sent through your ...
Nephrology. Renal vein thrombosis (RVT) is the formation of a clot in the vein that drains blood from the kidneys, ultimately leading to a reduction in the drainage of one or both kidneys and the possible migration of the clot to other parts of the body. [1] First described by German pathologist Friedrich Daniel von Recklinghausen in 1861, RVT ...
Hematuria or haematuria is defined as the presence of blood or red blood cells in the urine. [1] ". Gross hematuria" occurs when urine appears red, brown, or tea-colored due to the presence of blood. Hematuria may also be subtle and only detectable with a microscope or laboratory test. [2] Blood that enters and mixes with the urine can come ...
Ototoxic medication. Ototoxicity is defined as the toxic effect on the functioning of the inner ear, which may lead to temporary or permanent hearing loss (cochleotoxic) and balancing problems (vestibulotoxic). [1] Drugs or pharmaceutical agents inducing ototoxicity are regarded as ototoxic medications. Anatomy of the human ear.
Rare (0.01–0.1% incidence) Bradycardia. Hypertension (high blood pressure) Allergic reactions (e.g. dyspnoea (shortness of breath), bronchospasm, wheezing, angioneurotic oedema) Anaphylaxis. Changes in appetite. Paraesthesia (pins and needles) Hallucinations. Tremor.
Hemorrhagic cystitis or haemorrhagic cystitis is an inflammation of the bladder defined by lower urinary tract symptoms that include dysuria, hematuria, and hemorrhage. The disease can occur as a complication of cyclophosphamide, ifosfamide and radiation therapy. In addition to hemorrhagic cystitis, temporary hematuria can also be seen in ...
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