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Castleman disease (CD) is a lymphoproliferative disorder of unknown cause. [5] CD is associated with an increased risk of B-cell lymphoma. [5] Human herpesvirus 8 (HHV-8), also known as Kaposi sarcoma-associated herpesvirus (KSHV) has been found in some cases of multicentric Castleman disease (MCD). [5] [6] The HHV8 can give rise to an ...
Primary central nervous system lymphoma ( PCNSL ), also termed primary diffuse large B-cell lymphoma of the central nervous system (DLBCL-CNS), [ 2] is a primary intracranial tumor appearing mostly in patients with severe immunodeficiency (typically patients with AIDS ). It is a subtype and one of the most aggressive of the diffuse large B-cell ...
Diffuse large B-cell lymphoma ( DLBCL) is a cancer of B cells, a type of lymphocyte that is responsible for producing antibodies. It is the most common form of non-Hodgkin lymphoma among adults, [ 1] with an annual incidence of 7–8 cases per 100,000 people per year in the US and UK. [ 2][ 3] This cancer occurs primarily in older individuals ...
Plasmablastic lymphoma (PBL) is a type of large B-cell lymphoma recognized by the World Health Organization (WHO) in 2017 as belonging to a subgroup of lymphomas termed lymphoid neoplasms with plasmablastic differentiation. The other lymphoid neoplasms within this subgroup are: plasmablastic plasma cell lymphoma (or the plasmacytoma variant of ...
The B-cell lymphomas are types of lymphoma affecting B cells. Lymphomas are "blood cancers" in the lymph nodes. They develop more frequently in older adults and in immunocompromised individuals. B-cell lymphomas include both Hodgkin's lymphomas and most non-Hodgkin lymphomas. They are typically divided into low and high grade, typically ...
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Monoclonal B-cell lymphocytosis. Monoclonal B-cell lymphocytosis (MBL) is an asymptomatic condition in which individuals have increased blood levels of particular subtypes of monoclonal lymphocytes (i.e. an aberrant and potentially malignant group of lymphocytes produced by a single ancestral cell). This increase must persist for at least 3 ...
Variant form of nodular lymphocyte predominant Hodgkin lymphoma. T-cell/histiocyte-rich large B-cell lymphoma (THRLBCL) is a malignancy of B cells. B-cells are lymphocytes that normally function in the humoral immunity component of the adaptive immune system by secreting antibodies that, for example, bind to and neutralize invasive pathogens ...