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Diffuse large B-cell lymphoma ( DLBCL) is a cancer of B cells, a type of lymphocyte that is responsible for producing antibodies. It is the most common form of non-Hodgkin lymphoma among adults, [ 1] with an annual incidence of 7–8 cases per 100,000 people per year in the US and UK. [ 2][ 3] This cancer occurs primarily in older individuals ...
The five-year survival rate in the United States for all Hodgkin lymphoma subtypes is 85%, [4] while that for non-Hodgkin lymphomas is 69%. [15] Worldwide, lymphomas developed in 566,000 people in 2012 and caused 305,000 deaths. [16] They make up 3–4% of all cancers, making them as a group the seventh-most-common form.
Plasmablastic lymphoma (PBL) is a type of large B-cell lymphoma recognized by the World Health Organization (WHO) in 2017 as belonging to a subgroup of lymphomas termed lymphoid neoplasms with plasmablastic differentiation. The other lymphoid neoplasms within this subgroup are: plasmablastic plasma cell lymphoma (or the plasmacytoma variant of ...
The B-cell lymphomas are types of lymphoma affecting B cells. Lymphomas are "blood cancers" in the lymph nodes. They develop more frequently in older adults and in immunocompromised individuals. B-cell lymphomas include both Hodgkin's lymphomas and most non-Hodgkin lymphomas. They are typically divided into low and high grade, typically ...
Deaths. 231,400 (2015) [ 5] Non-Hodgkin lymphoma ( NHL ), also known as non-Hodgkin's lymphoma, is a group of blood cancers that includes all types of lymphomas except Hodgkin lymphomas. [ 1] Symptoms include enlarged lymph nodes, fever, night sweats, weight loss, and tiredness. [ 1] Other symptoms may include bone pain, chest pain, or ...
These earlier used chemotherapy regimens (e.g. the CHOP regimen consisting of three chemotherapy drugs (cyclophosphamide, hydroxydoxorubicin, and oncovin) plus a glucocorticoid, either prednisone or prednisolone) achieve complete response rates of 48% to 85%, 3-year overall survival rates of 50% to 64%, and 5-year overall survival rates of 46% ...
In general, overall survival rates after 5, 10, and 15 years of treatment have been 95%, 85%, and 78% respectively. While the response to these therapeutic regimens has been very good, ~33% of treated patients have experience a recurrence of their lymphoma in the salivary/lacrimal glands, lymph nodes, or other sites. [20]
Primary central nervous system lymphoma ( PCNSL ), also termed primary diffuse large B-cell lymphoma of the central nervous system (DLBCL-CNS), [ 2] is a primary intracranial tumor appearing mostly in patients with severe immunodeficiency (typically patients with AIDS ). It is a subtype and one of the most aggressive of the diffuse large B-cell ...
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