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The phrase entourage effect was introduced in 1999. [12] [13] While originally identified as a novel method of endocannabinoid regulation by which multiple endogenous chemical species display a cooperative effect in eliciting a cellular response, the term has evolved to describe the polypharmacy effects of combined cannabis phytochemicals or whole plant extracts. [14]
Nabiximols (brand name Sativex) is an aerosolized mist for oral administration containing a near 1:1 ratio of CBD and THC. [53] Also included are minor cannabinoids and terpenoids, ethanol and propylene glycol excipients, and peppermint flavoring. [54]
Cannabis in Virginia is legal for medical use and recreational use. The first medical marijuana dispensary opened in August 2020, [1] and adult recreational use became legalized in July 2021. [2][3] In April 2020, Virginia Governor Ralph Northam approved a bill to decriminalize simple marijuana possession, which took effect July 2020.
[4] [5] It may be supplied as CBD oil containing only CBD as the active ingredient (excluding THC or terpenes), CBD-dominant hemp extract oil, capsules, dried cannabis, or prescription liquid solution. [7] [21] CBD does not have the same psychoactivity as THC, [24] [25] and can modulate the psychoactive effects of THC on the body if both are ...
The subjective effects of sativas and indicas are said to differ, but the ratio of tetrahydrocannabinol (THC) to cannabidiol (CBD) in most named drug varieties of both types is similar (averaging about 200:1). Unlike most commercially developed strains, indica landraces exhibit plants with varying THC/CBD ratios. [7]
Despite the CBD and THC having the same molecular weight, multiple analytical methods are able to differentiate them. [11] "on the recovery of both THC (86.7−90.0%) and CBD (92.3−95.6%). The slightly lower recovery of THC can be explained by the fact that THC is less polar than CBD and more likely to remain in the nonpolar sunflower oil." [11]
In pharmacology, potency or biological potency[1] is a measure of a drug's biological activity expressed in terms of the dose required to produce a pharmacological effect of given intensity. [2] A highly potent drug (e.g., fentanyl, clonazepam, risperidone, benperidol, bumetanide) evokes a given response at low concentrations, while a drug of ...
Cannabis[ b ] (/ ˈkænəbɪs /), or commonly known as marijuana[ 3 ] (/ ˌmærəˈwɑːnə /), is a non-chemically uniform drug from the cannabis plant. Native to Central or South Asia, the cannabis plant has been used as a drug for both recreational and entheogenic purposes and in various traditional medicines for centuries.