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  2. Weight Loss and Improvement in Comorbidity: Differences at 5%,...

    www.ncbi.nlm.nih.gov/pmc/articles/PMC5497590

    A 5% for weight loss from baseline is generally accepted as a “clinically meaningful” amount. 1 Certainly, the 2013 Obesity Guidelines recommended weight loss of 5–10% as the goal for medically supervised weight loss. 2 Further, the US Food and Drug Administration Draft Guidance for medications for management of obesity has as one of the ...

  3. In this review, we assessed the available literature describing the effect of categorical weight losses of ≥5%, ≥10%, and ≥15% on obesity-related comorbidities and complications, and challenge the concept of clinically meaningful weight loss to go beyond percentage change in total body weight.

  4. Full article: What is clinically relevant weight loss for your...

    www.tandfonline.com/doi/full/10.1080/00325481.2022.2051366

    In this review, we assessed the available literature describing the effect of categorical weight losses of ≥5%, ≥10%, and ≥15% on obesity-related comorbidities and complications, and challenge the concept of clinically meaningful weight loss to go beyond percentage change in total body weight.

  5. Long-Term Weight Loss Strategies for Obesity - PMC

    www.ncbi.nlm.nih.gov/pmc/articles/PMC8427732

    A meta-analysis indicates that patients who adhere to a diet and exercise program can achieve clinically meaningful weight loss: −6.29 kg (95% CI −7.33 to −5.25) after 12 to 18 months . The additive effects of exercise on weight loss can be numerically modest, but statistically significant [+1.14 kgs lost (95% CI 0.21-2.07)] ( 51 ).

  6. The Mayo Clinic Diet: A weight-loss program for life

    www.mayoclinic.org/healthy-lifestyle/weight-loss/in-depth/mayo-clinic-diet/art...

    The Mayo Clinic Diet is a long-term weight management program created by a team of weight-loss experts at Mayo Clinic. The program has been updated and is designed to help you reshape your lifestyle by adopting healthy new habits and breaking unhealthy old ones.

  7. Effects of Clinically Significant Weight Loss with Exercise...

    www.ncbi.nlm.nih.gov/pmc/articles/PMC4814330

    Clinically significant weight loss (CWL) is defined as at least a 5% reduction in weight from the baseline level (1), and associated with improvements in cardiometabolic risk factors, such as beneficial changes in lipid profile and insulin sensitivity (1, 2, 3).

  8. Mechanisms, Pathophysiology, and Management of Obesity

    www.nejm.org/doi/full/10.1056/NEJMra1514009

    Moderate weight loss, defined as a 5 to 10% reduction in baseline weight, is associated with clinically meaningful improvements in obesity-related metabolic risk factors and coexisting...

  9. What is clinically relevant weight loss for your patients and how...

    www.tandfonline.com/doi/pdf/10.1080/00325481.2022.2051366

    In line with newly released clinical practice guidelines, weight loss targets for people living with obesity should be defined individually based on their clinical profile, and progress measured in the context of improvements in health outcomes, rather than weight loss alone.

  10. Integrating Weight Management in Primary Care - Harvard...

    info.primarycare.hms.harvard.edu/perspectives/articles/integrating-weight...

    Effective obesity treatment, commonly defined as a clinically meaningful weight loss of greater than 5 percent, can improve chronic conditions such as diabetes, hypertension, and dyslipidemia.

  11. Enhanced weight-loss counseling helps about one third of obese patients achieve long-term, clinically meaningful weight loss.