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In microbiology, in vivo is often used to refer to experimentation done in a whole organism, rather than in live isolated cells, for example, cultured cells derived from biopsies. In this situation, the more specific term is ex vivo. Once cells are disrupted and individual parts are tested or analyzed, this is known as in vitro. [citation needed]
Ivacaftor is a medication used to treat cystic fibrosis in people with certain mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene (primarily the G551D mutation), who account for 4–5% cases of cystic fibrosis. [ 5][ 6] It is also included in combination medications, lumacaftor/ivacaftor, tezacaftor/ivacaftor, and ...
In microbiology, the minimum inhibitory concentration ( MIC) is the lowest concentration of a chemical, usually a drug, which prevents visible in vitro growth of bacteria or fungi. [ 1][ 2] MIC testing is performed in both diagnostic [ 1][ 2] and drug discovery laboratories. [ 3][ 4] The MIC is determined by preparing a dilution series of the ...
In vitro to in vivo extrapolation (IVIVE) refers to the qualitative or quantitative transposition of experimental results or observations made in vitro to predict phenomena in vivo, biological organisms. The problem of transposing in vitro results is particularly acute in areas such as toxicology where animal experiments are being phased out ...
X-inactivation is an early developmental process in mammalian females that transcriptionally silences one of the pair of X chromosomes, thus providing dosage equivalence between males and females (see dosage compensation ). The process is regulated by several factors, including a region of chromosome X called the X-inactivation center (XIC).
Asus was founded in Taipei in 1989 [ 13 ] by T.H. Tung, Ted Hsu, Wayne Hsieh and M.T. Liao, [ 14 ] all four having previously worked at Acer as hardware engineers. At this time, Taiwan had yet to establish a leading position in the computer hardware business. Intel Corporation would supply any new processors to more established companies like ...
IVIVC. An in-vitro in-vivo correlation ( IVIVC) has been defined by the U.S. Food and Drug Administration (FDA) as "a predictive mathematical model describing the relationship between an in-vitro property of a dosage form and an in-vivo response". Generally, the in-vitro property is the rate or extent of drug dissolution or release while the in ...
t. e. Pronunciation in Wikipedia should be transcribed using the International Phonetic Alphabet (IPA), except in the particular cases noted below. For English pronunciations, broad diaphonemic transcriptions should be used; these are intended to provide a correct interpretation regardless of the reader's accent.