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On March 1, 2021, two days after the first delivery of the vaccine, the NACI announced that it would recommend that the Oxford-AstraZeneca vaccine not be given to patients older than 65 due to “the insufficiency of evidence of efficacy in this age group at this time.” [247] This recommendation was based on clinical trial data that only went ...
As the second vaccinations became more widely available in June 2021, Manitoba became the first province in Canada to offer a voluntary vaccine passport. [ 2 ] As Canada was emerging from the fourth wave in mid-August—which had been dominated by the highly contagious SARS-CoV-2 Delta variant , [ 3 ] governments at different levels were ...
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[115] [116] [117] AstraZeneca responded to the criticism by agreeing to carry out a new multi-country trial using the lower dose, which had led to the 90% claim. [ 118 ] The full publication of the interim results from four ongoing Phase III trials on 8 December allowed regulators and scientists to begin evaluating the vaccine's efficacy. [ 119 ]
In the overall trial population, OS results numerically favored datopotamab deruxtecan compared to docetaxel (12.9 vs. 11.8 months) but did not reach statistical significance (hazard ratio [HR] 0. ...
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The trial, known as CAPItello-290, was testing whether the drug combination improved overall survival in patients with inoperable or metastatic triple-negative breast cancer versus the older and ...
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