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The HAIR-AN syndrome is a rare subtype of polycystic ovary syndrome (PCOS) characterized by hyperandrogenism (HA), insulin resistance (IR) and acanthosis nigricans (AN). The symptoms of the HAIR-AN syndrome are largely due to severe insulin resistance, which can be secondary to blocking antibodies against the insulin receptor or genetically absent/reduced insulin receptor number/function.
Trichotillomania. Trichotillomania ( TTM ), also known as hair-pulling disorder or compulsive hair pulling, is a mental disorder characterized by a long-term urge that results in the pulling out of one's own hair. [ 2][ 4] A brief positive feeling may occur as hair is removed. [ 5] Efforts to stop pulling hair typically fail.
Constitutional Symptoms. Unexplained weight loss: Weight loss that is unintended and not explained by diet, exercise or other illness may be a warning sign of many types of cancer. Unexplained pain: Pain that persists, has no clear cause, and does not respond to treatment may be a warning sign of many types of cancers.
Uncombable hair syndrome ( UHS) is a rare structural anomaly of the hair with a variable degree of effect. It is characterized by hair that is silvery, dry, frizzy, wiry, and impossible to comb. [ 4] It was first reported in the early 20th century. [ 5] It typically becomes apparent between the ages of 3 months and 12 years. [ 6]
A Pancoast tumor is a tumor of the apex of the lung. It is a type of lung cancer defined primarily by its location situated at the top end of either the right or left lung. It typically spreads to nearby tissues such as the ribs and vertebrae. Most Pancoast tumors are non-small-cell lung cancers . The growing tumor can cause compression of many ...
Muir–Torre syndrome is a rare hereditary, autosomal dominant cancer syndrome [ 1]: 663 that is thought to be a subtype of HNPCC (Lynch syndrome). Individuals are prone to develop cancers of the colon, genitourinary tract, and skin lesions, such as keratoacanthomas and sebaceous tumors. The genes affected are MLH1, [ 2] MSH2, [ 3] and more ...
Hard lump with a scaly top or ulceration. [ 1] Cutaneous squamous-cell carcinoma ( cSCC ), also known as squamous-cell carcinoma of the skin or squamous-cell skin cancer, is one of the three principal types of skin cancer, alongside basal-cell carcinoma and melanoma. [ 10] cSCC typically presents as a hard lump with a scaly surface, though it ...
Menkes disease. Menkes disease ( MNK ), also known as Menkes syndrome, [ 1][ 2] is an X-linked recessive disorder caused by mutations in genes coding for the copper-transport protein ATP7A, [ 3] leading to copper deficiency. [ 4][ 5] Characteristic findings include kinky hair, growth failure, and nervous system deterioration.
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