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Infobox references. 2,3,7,8-Tetrachlorodibenzo-p-dioxin ( TCDD) is a polychlorinated dibenzo -p- dioxin (sometimes shortened, though inaccurately, to simply 'dioxin') [ 3] with the chemical formula C 12 H 4 Cl 4 O 2. Pure TCDD is a colorless solid with no distinguishable odor at room temperature.
Polychlorinated dibenzo -p- dioxins (PCDDs), or simply dioxins. PCDDs are derivatives of dibenzo -p- dioxin. There are 75 PCDD congeners, differing in the number and location of chlorine atoms, and 7 of them are specifically toxic, the most toxic being 2,3,7,8-tetrachlorodibenzodioxin (TCDD). Polychlorinated dibenzofurans (PCDFs), or furans.
One of the most toxic compounds known, 2,3,7,8-tetrachlorodibenzo[p]dioxin, a PCDD, is assigned a TEF of 1. [54] In June 2020, State Impact of Pennsylvania stated that "In 1979, the EPA banned the use of PCBs, but they still exist in some products produced before 1979. They persist in the environment because they bind to sediments and soils.
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2,3,7,8-Tetrachlorodibenzofuran ( TCDF) is a polychlorinated dibenzofuran with a chemical formula of C 12 H 4 Cl 4 O. TCDF is part of the chlorinated benzofuran (CDF) family that contain between 1 and 8 chlorine atoms attached to the parent dibenzofuran ring system. The CDF family includes 135 compounds, of which only a few have been studied.
The aryl hydrocarbon receptor (also known as AhR, AHR, ahr, ahR, AH receptor, or as the dioxin receptor) is a protein that in humans is encoded by the AHR gene. The aryl hydrocarbon receptor is a transcription factor that regulates gene expression. It was originally thought to function primarily as a sensor of xenobiotic chemicals and also as ...
The half-lives of Hexachlorodibenzo-p-dioxin and octachlorodibenzo-p-dioxin were estimated to be 3.5 and 2 years, respectively. The effects of chlorodibenzo-p-dioxin exposure was examined in rats over a 13-week period. Hepatic accumulation was associated with alterations of several biochemical parameters.
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