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Conjugated estrogens was introduced for medical use under the brand name Premarin in Canada in 1941, in the United States in 1942, and in the United Kingdom in 1956. [80] The manufacturer of Premarin secretly paid gynecologist Robert A. Wilson to promote its use by menopausal women in his 1966 book, Feminine Forever, leading to increased sales ...
Esterified estrogens (EEs), sold under the brand names Estratab and Menest among others, is an estrogen medication which is used hormone therapy for menopausal symptoms and low sex hormone levels in women, to treat breast cancer in both women and men, and to treat prostate cancer in men.
In addition, there is a single preparation (brand name FemHRT) containing very low doses of EE (2.5 and 5 μg) plus a progestin in an oral tablet that remains in use for menopausal hormone therapy. [ 12 ] [ 26 ] EE was previously available by itself under brand names like Estinyl and Lynoral in the form of 0.002, 0.01, 0.02, 0.025, 0.05, 0.1, 0 ...
Conjugated estrogens (Premarin) – 25 mg/vial; Estradiol cypionate (Depo-Estradiol, Estradiol Cypionate) – 5 mg/mL (1 mg/mL and 3 mg/mL discontinued) Estradiol valerate (Delestrogen, Estradiol Valerate) – 10 mg/mL, 20 mg/mL, 40 mg/mL; Polyestradiol phosphate (Estradurin) was previously available in the U.S. but was discontinued.
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Estradiol valerate is an estradiol ester, or a prodrug of estradiol. [ 16][ 5] As such, it is an estrogen, or an agonist of the estrogen receptors. [ 5][ 16] The affinity of estradiol valerate for the estrogen receptor is approximately 50 times lower than that of estradiol. [ 4]
Estradiol ( E2) is a medication and naturally occurring steroid hormone. [ 11][ 12][ 13] It is an estrogen and is used mainly in menopausal hormone therapy and to treat low sex hormone levels in women. [ 11][ 14] It is also used in hormonal birth control for women, in feminizing hormone therapy for transgender women, and in the treatment of ...
Estradiol benzoate is an estradiol ester, or a prodrug of estradiol. [ 4][ 5] As such, it is an estrogen, or an agonist of the estrogen receptors. [ 4][ 5] Estradiol benzoate has very low affinity for the ERs, on the order of 100-fold less than that of estradiol. [ 64] As such, estradiol benzoate is regarded as essentially inactive in terms of ...
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